Read e-book online Genomic Elements in Health, Disease and Evolution: Junk DNA PDF

By Kyriacos Felekkis,Konstantinos Voskarides

ISBN-10: 1493930699

ISBN-13: 9781493930692

ISBN-10: 1493943650

ISBN-13: 9781493943654

Over ninety eight% of the human genome includes non-coding DNA sequences. for a few years molecular biologists noted this section of the genome because the “junk” DNA because it doesn't code for any “useful” protein product. over the past years this thought replaced considerably as scientists came across that an enormous a part of this DNA includes a number of genomic parts that experience vital roles in phone body structure. Genomic parts corresponding to non-coding RNAs, transposons, splicing RNAs, DNA repeats and others have been proven to play an important position in regulating gene expression. moreover, these kinds of components have been implicated to give a contribution within the pathogenesis or development of varied human illnesses. during this book, the editor will try and describe these kind of genomic components that represent the junk DNA of the genome. for each genomic point, the physiologic function within the organism, its position in evolution and any attainable involvement in human ailments may be mentioned. also, interplay among those components in common or pathologic situation should be mentioned. due to the fact that a large number of new wisdom is generated day-by-day with reference to those genomic parts, this e-book will try and mix the entire info in one ebook which can function a reference for destiny reports. the 1st half will speak about RNA components resembling microRNAs, lengthy non-coding RNAs, piRNAs and splicing RNAs. the second one a part of the e-book will care for transposons, retrotransposons and DNA transposons. ultimately the 3rd a part of the booklet will speak about DNA parts that come with DNA repeats, conserved non-coding sequences, distal genomic parts, introns, pseudogenes, CpG islands and telomeres. For miRNAs and CNVs a separate bankruptcy may be devoted to their position in human ailments for the reason that an intensive quantity of knowledge exists approximately those elements.

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Genomic Elements in Health, Disease and Evolution: Junk DNA by Kyriacos Felekkis,Konstantinos Voskarides

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