By Thomas Lufkin
ISBN-10: 0444514988
ISBN-13: 9780444514981
The amino acid series of the homeodomain, in addition to the presence of different conserved protein domain names, has allowed the category of homeodomain-containing proteins (homeoproteins) into over thirty separate households (e.g. Hox, Dlx, Msx, Otx, Hmx, Cdx etc.). in lots of circumstances a unmarried gene has been proven to completely direct the morphogenesis and improvement of a fancy tissue, organ or maybe a whole physique section. but how this "master" regulatory skill of homeoproteins features on the molecular point to a wide measure nonetheless is still a secret, partly because of our constrained realizing of the character of either homeoprotein transcriptional cofactors or even extra elusively, the downstream pursuits of homeoprotein functionality.
In the reports provided right here it really is constrained basically to what has been discovered in vertebrate structures, largely concentrating on the mouse, as a result of the strengths of the technical techniques at present present in murine developmental genetics that aren't but to be had to a similar measure in different vertebrate species. regardless of this mammalian predilection, a typical thread to every of those stories is the underlying value of what has been discovered approximately homeoprotein functionality in different animal species, relatively arthropods like Drosophila.
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Murine Homeobox Gene Control of Embryonic Patterning and Organogenesis (Advances in Developmental Biology) by Thomas Lufkin
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