Get Regulation of Alternative Splicing (Progress in Molecular PDF

By Philippe Jeanteur

ISBN-10: 3540438335

ISBN-13: 9783540438335

ISBN-10: 3642078583

ISBN-13: 9783642078583

the invention in 1977 that genes are cut up into exons and introns has performed away with the single gene - one protein dogma. certainly, the removing of introns from the first RNA transcript isn't really inevitably trouble-free due to the fact there's non-compulsory pathways resulting in diverse messenger RNAs and therefore to diverse proteins. Examples of such another splicing mechanism disguise all fields of biology. in addition, there are many occurrences the place deviant splicing could have pathological results. regardless of the excessive variety of particular instances of other splicing, it used to be now not until eventually lately that the generality and volume of this phenomenon used to be totally liked. A superficial examining of the initial series of the human genome released in 2001 resulted in the remarkable, or even deceiving to many scientists, low variety of genes (around 32,000) which contrasted with the a lot greater determine round 150,000 which was once formerly anticipated. makes an attempt to make a world review of using substitute splicing are contemporary and depend primarily at the comparability of genomic mRNA and EST sequences as reviewed via Thanaraj and Stamm within the first bankruptcy of this quantity. most up-to-date estimates recommend that 40-60% of human genes may be on the other hand spliced, in preference to approximately 22% for C. elegans.

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Regulation of Alternative Splicing (Progress in Molecular and Subcellular Biology) by Philippe Jeanteur


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